Evelo Biosciences Announces Biomarker Data Showing EDP1815 is an Orally Delivered Dual Cytokine Inhibitor for Inflammatory Diseases

CAMBRIDGE, Mass., March 02, 2020 (GLOBE NEWSWIRE) — Evelo Biosciences, Inc. (Nasdaq:EVLO), a clinical stage biotechnology company developing a new modality of orally delivered, systemically acting biologics, today announced biomarker data for EDP1815, its lead inflammation product candidate. Interim data from individuals in the ongoing Phase 1b clinical trial showed marked activity on multiple individual systemic markers of inflammation, including interleukin-6 (IL-6) and interleukin-8 (IL-8). IL-6 and IL-8 are well-established mediators of potentially harmful effects in patients with inflammatory diseases and these data support the therapeutic potential of EDP1815 to treat classic inflammatory diseases such as psoriasis.

“These results support our central thesis that we can treat systemic inflammation by targeting SINTAX™, the small intestinal axis. This radical new understanding of how inflammation is controlled is the foundation of our approach to developing effective, safe, orally delivered medicines,” said Mark Bodmer, Ph.D., chief scientific officer of Evelo. “This analysis of specific clinical biomarkers provides further evidence that EDP1815 has the potential to address systemic inflammation by targeting the functional connections in the small intestine with the rest of the body. Concurrent reductions in the production of multiple inflammatory cytokines by a well-tolerated oral agent is a unique profile for the treatment of diseases involving inflammation.”

Evelo previously reported interim data showing reduced production of systemic markers of inflammation in individuals with mild to moderate psoriasis dosed with EDP1815. The detailed analysis of the previously reported data show that EDP1815 highlights the individual inflammatory cytokines and chemokines that were modulated.

Six cytokines were reliably detected in the biomarker assay. The results for IL-6 and IL-8 are shown in the waterfall plots below. Treatment with EDP1815 caused a pronounced downward shift in production compared to placebo during the 28-day treatment period. Similar, slightly less pronounced reductions were seen for TNFa and IL1b. No effect was seen on IFN-g or IL-10.

A Media Snippet accompanying this announcement is available by clicking on the image or link below:

EDP1815 reduces production of IL-6 and IL-8 from human blood cells after 28 days of treatment