SAN FRANCISCO, CA–(Marketwired – April 27, 2017) – Positive results in a Phase 1b trial of DURECT Corp.’s (NASDAQ: DRRX) candidate for the treatment of nonalcoholic steatohepatitis (NASH), which were presented at the 2017 International Liver Congress, prompted comments from a pair of analysts.
Included in this article is: DURECT Corp.
In an April 23 conference update, analyst David Sherman of LifeSci Capital commented on the results of DURECT Corp.’s Phase 1b study of DUR-928, noting the compound “was well tolerated overall,” that the data supported ongoing evaluation of the therapy, and that “investigators speculated on the plausibility of a therapeutic effect due to biomarker reductions at approximately 12 hours following dosing.”
In an April 25 Laidlaw & Company research report, analyst Francois Brisebois observed that at its lowest dose, DUR-928 “showed reduction in liver function and injury biomarkers after only 12 hours. Additionally, inflammation markers and mediators such as high sensitivity C-reactive protein (hsCRP) and IL-18, as well as CK18 (cell death biomarker), were reduced in NASH (especially in cirrhotics). The full data set confirmed these findings with a single dose, which is a real positive in our opinion.”
The Laidlaw analyst also noted that with the Phase 3 PERSIST trial “of Posimir for post-operative pain expected to read-out by year end-2017, IND [investigational new drug] filings in both liver and kidney programs around mid-2017 and initiation of a Phase 2 trial for DUR-928 in mid-2017 for primary sclerosing cholangitis (PSC), 2017 should be an exciting year for DRRX.”
According to a report by Reuters, the market for NASH, also known as nonalcoholic fatty liver disease, “is forecast to be $20 billion to $35 billion as populations with fatty diets increasingly fall victim to a condition with no approved treatments.”
Continue reading this article: Trial Results Set Up DURECT Corp. for ‘Exciting Year’
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